Greg Ryslik

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Identification of Non-Random Somatic Mutation Clustering in Proteins
05 February 2015 from 4:00 PM to 5:00 PM
201 Thomas Building
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Human cancer is a genetic disease that is caused by the accumulation of somatic mutations in tumor suppressors and oncogenes. In the case of oncogenes, recent theory suggests that there 
are only a few key “driver” mutations responsible for tumorigenesis and that they often cluster in specific regions of the protein.  I will present several methodologies that identify these mutational clusters while accounting for protein tertiary and quaternary structure. Applications to drug discovery will also be discussed.

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