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David Madigan, Columbia University

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Large Observational Healthcare Studies: Challenges, Pitfalls, and Future Directions
14 April 2016 from 4:00 PM to 5:00 PM
201 Thomas Bldg
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David Madigan

Observational healthcare data, such as administrative claims and electronic health records, play an increasingly prominent role in healthcare. Pharmacoepidemiologic studies in particular routinely estimate temporal associations between medical product exposure and subsequent health outcomes of interest and such studies influence prescribing patterns and healthcare policy more generally. Some authors have questioned the reliability and accuracy of such studies, but few previous efforts have attempted to measure their performance. We have conducted a series of experiments to empirically measure the performance of various observational study designs with regard to predictive accuracy for discriminating between true drug effects and negative controls. I describe this work briefly, and then describe ongoing efforts to generate more reliable evidence from observational data. My talk will highlight areas for future research and development

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