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Olga Vitek, Northeastern University

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Statistical methods and tools for quantitative mass spectrometry-based proteomics
04 February 2016 from 4:00 PM to 5:00 PM
201 Thomas
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Mass spectrometry-based proteomics studies proteins in complex biological mixtures. Stochastic variation and uncertainty are hallmarks of proteomic experiments, and statistical experimental design and analysis are key. Many statistical issues can be solved by a thorough application of classical statistical techniques, or by applying methods developed for experiments studying gene expression. However, there are numerous other aspects that require the development of new specialized statistical tools.

This talk will briefly introduce mass spectrometry-based proteomic workflows and the associated statistical challenges. Using several case studies, we will discuss the use of standard statistical tools in this context, as well as opportunities that this area offers for research in applied statistics.



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