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Bruce Turnbull, Cornell University

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Sequential Statistics and Clinical Trials — from Biblical Times to Modern Day Adaptive Designs
When
09 November 2017 from 4:00 PM to 5:00 PM
Where
201 Thomas Building
Contact Name
Lorey Burghard
Contact Phone
814-867-6326
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   The title says it all! We start with the Flood and end with end with the latest (2016) FDA Guidance on adaptive designs for clinical trials. We discuss the use of sequential statistical methodology for monitoring efficacy and safety during the conduct of a clinical trial and how adaptive design changes in mid-course can lead to efficiencies. The cost of these trials can be many tens of millions of dollars; so even small reductions in sample size and trial duration are well worthwhile. As well, aarly stopping either for harm, futility or for a positive result has obvious ethical benefits for patients inside or outside the trial.

Bruce Turnbull is Professor Emeritus in the Department of Statistical Science at Cornell University.

Retiring in 2015, he remains active on Campus, conducting research and supervising PhD students.

Turnbull is the author of over 135 scholarly articles and the author (with Chris Jennison) of the book

"Group Sequential Methods with Applications to Clinical Trials". He has given short courses at a number of professional workshops.

Bruce Turnbull is Professor Emeritus in the Department of Statistical Science at Cornell University.

Retiring in 2015, he remains active on Campus, conducting research and supervising PhD students.

Turnbull is the author of over 135 scholarly articles and the author (with Chris Jennison) of the book

"Group Sequential Methods with Applications to Clinical Trials". He has given short courses at a number of professional workshops.

As a consultant, he has been heavily involved with the design, monitoring and analysis on clinical trials for Government agencies (NIH, VA), for university/hospital based trials and for the pharma industry.   He has served or is currently serving on trial executive committees, scientific advisory boards and, of particular interest for this Conference, a large number of DSMBs.

He has served on the editorial board of several statistical journals and currently for Chapman & Hall/CRC Biostatistics book series.

 Turnbull is a holder of the Snedecor Award and is a Fellow of the American Statistical Association




 

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